Sunekos vs. Polynucleotides: A Clinical Comparison for Men's Under-Eye Rejuvenation by our Manchester Doctors.
- Dr Andrew Mabey
- 1 day ago
- 3 min read
The Anatomical Basis of Periorbital Ageing in Men
The periorbital region, the area around the eyes, features the thinnest cutaneous layer of the body. Consequently, it is one of the first anatomical areas to exhibit signs of ageing. This process is multifactorial, primarily driven by the progressive degradation of collagen and elastin, key proteins in the dermal extracellular matrix.
This intrinsic ageing, coupled with extrinsic factors and age-related volume loss in the mid-face, contributes to the clinical presentation of wrinkles, dark circles, and prolapse of orbital fat, commonly known as 'eye bags'. Many individuals first attempt to address these concerns using potent topical actives, such as retinoids or vitamin C serums. However, the application of these products (in some people) can lead to irritation.
Limitations of Traditional Hyaluronic Acid Tear Trough Fillers
Historically, hyaluronic acid (HA) dermal fillers were the primary injectable intervention for addressing volume deficits in the tear trough. However, patient suitability is a significant limiting factor. Due to the unique lymphatic drainage and thin tissue of this area, adverse events can include persistent oedema (swelling) and the Tyndall effect, a bluish discolouration.
Consequently, clinical practice is increasingly shifting towards regenerative treatments that aim to improve the intrinsic quality and structure of the skin itself, rather than simply occupying space.
A Note on the Evidence Base in Aesthetic Medicine
As medical doctors, with Dr. Andrew having an additional degree in medical research, we are committed to a rigorous, evidence-based methodology. It is important for patients to understand that many aesthetic injectables are regulated as ‘medical devices’. Unlike pharmaceutical drugs, they are not always required to undergo the same extensive, large-scale randomised controlled trials.
Claims regarding their effectiveness can be based on smaller cohort studies, in-vitro data, or specific experimental conditions.
Therefore, we approach all interventions with a necessary degree of clinical scrutiny. Our treatment protocols are based on a critical appraisal of all available data to ensure we are offering interventions with a strong profile for safety and efficacy.
Two such treatments that have gained prominence for periorbital rejuvenation are Sunekos and Polynucleotides.
Comparative Analysis: Sunekos and Polynucleotides
These treatments both function as bio-stimulators but possess distinct mechanisms of action.
Mechanism of Action: Sunekos
Sunekos is an injectable solution comprised of a specific, patented formulation of amino acids and low molecular weight hyaluronic acid.
Components
A precise blend of amino acids (Glycine, L-Proline, L-Leucine, etc.) acts as a direct precursor for collagen and elastin synthesis.
Physiological Effect
When introduced into the dermis, it directly stimulates the metabolic activity of fibroblasts. This targeted stimulation results in the physiological production of new structural proteins, thereby improving dermal density and viscoelasticity.
Treatment Protocol
A standard protocol involves a minimum of three sessions at specified intervals to achieve optimal results.
Mechanism of Action: Polynucleotides
Polynucleotides are highly purified, injectable DNA fractions derived from salmon or trout, processed to ensure biocompatibility and safety.
Components
Long chains of nucleotides that mimic human DNA.
Physiological Effect
Their primary mechanism is the stimulation of cell receptors, promoting enhanced collagen and elastin production for dermal thickening. They also exhibit secondary benefits:
Improved Hydration: They bind water, leading to improved tissue hydration.
Antioxidant Activity: They function as effective scavengers of free radicals, reducing cellular damage from oxidative stress.
Treatment Protocol
Similar to Sunekos, optimal outcomes are typically observed following a course of three treatment sessions.
Clinical Verdict and Patient Selection
We have achieved very good results with both treatments; however, the selection of the appropriate agent is contingent upon the patient's specific clinical presentation.
Indications for Sunekos | Indications for Polynucleotides |
Often indicated for patients presenting with fine lines, dermal atrophy (thinning skin), and loss of elasticity. | A strong option for patients with concerns related to skin dehydration, impaired skin quality, and darker circles where improved dermal thickness would be beneficial. |
Patient selection is paramount. Individuals with significant tissue laxity or substantial volume loss may require more intensive interventions, such as CO2 laser resurfacing or a surgical referral for a lower blepharoplasty.
Establishing a Bespoke Treatment Protocol for Sunekos and Polynucleotides in our Manchester clinic.
Determining the most suitable treatment modality requires a formal consultation with a clinician who possesses a strong understanding of both dermatology and advanced aesthetic principles. This assessment allows for a thorough examination of your anatomy and a detailed discussion of your aesthetic goals, forming the basis of a safe and effective, evidence-based treatment plan.
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